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Medicines that inhibit CYP2D6 activity, such as paroxetine and quinidine, might induce lowered clearance of oxycodone which could lead to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by thirteen%, and t½ elim.Ask your medical professional or pharmacist if you sho